Tamar Schlick

Professor of Chemistry; Department of Biochemistry, New York University School of Medicine Courant Institute of Mathematical Science (Department of Mathematics and Computer Science)
B.S., Wayne State Univeristy; Ph.D., New York University Courant Institute of Mathematical Sciences; Postdoctoral research, NYU and Weizmann Institute, Israel

Phone: 212-998-3596
Office: Silver Center, 100 Washington Square East, Room 1021A
Personal Homepage
Lab Homepage

Areas of Research/Interest
Molecular mechanics and dynamics, computational and structural biology, DNA supercoiling, RNA structure and genomics, and DNA/protein interactions. Biomolecular Modeling, Computational Biology Courses


N. Kim, H. H. Gan and T. Schlick, A Computational Approach for Design of RNA Pools for Graph In Vitro Selection of RNA, RNA, In Press (2007).

R. Radhakrishnan, and T. Schlick, Correct and Incorrect Nucleotide Incorporation Pathways in DNA Polymerase Beta’s, Biochem. Biophys. Res. Comm. 350, 521–529 (2006).

G. Arya and T. Schlick, Role of Histone Tails in Chromatin Folding Revealed by a New Mesoscopic Oligonucleosome Model, Proc. Nat. Acad. Sci. USA 103, 16236–16241 (2006).

M. Foley, K. Arora, and T. Schlick, Sequential Side-chain Residue Motions Transform the Binary into the Ternary State of DNA Polymerase Lambda, Biophys. J. 91, 3182–3195 (2006

G. Arya, Q. Zhang, and T. Schlick, Flexible Histone Tails in a New Mesopscopic Model of Oligonucleosomes, Biophys. J.  91, 133–150 (2006).

R. Radhakrishnan, K. Arora, Y. Wang, W. Beard, S. Wilson, and T. Schlick, Regulation of DNA Repair Fidelity by Molecular Checkpoints: "Gates" in DNA Polymerase Beta's Substrate Selection, Biochem. 45, 15142–15156 (2006)

Q. Zhang and T. Schlick, Stereochemistry and Position-Dependent Effects of Carcinogens on TATA/TBP Binding, Biophys. J. 90, 1865–1877 (2006).

T. Schlick, RNA: The Cousin Left Behind Becomes a Star, in Computational Studies of DNA and RNA, pp. 259–281, J. Sponer and F. Lankas, Editors, Springer Verlag, Dordrecht, The Netherlands (2006).

Y. Wang, K. Arora, and T. Schlick, Subtle but Variable Conformational Rearrangements in the Replication Cycle of Sulfolobus solfactarius P2 DNA polymerase IV (Dpo4) May Accommodate Lesion Bypass,  Prot. Sci. 15, 135–151 (2006).

B. Sampoli Benitez, K. Arora, and T. Schlick, In Silico Studies of the African Swine Fever Virus DNA Polymerase X support an Induced-Fit Mechanism, Biophys. J. 90, 42–56 (2006).

U. Laserson, H. H. Gan and T. Schlick, Predicting Candidate Genomic Sequences that Correspond to Synthetic Functional RNA Motifs, Nuc. Acids Res. 33, 6057–6069 (2005).

R. Radhakrishnan and T. Schlick, Fidelity Discrimination in DNA Polymerase Beta: Differing Closing Profiles for a Mismatched (G:A) Versus Matched (G:C) Base Pair, J. Amer. Chem. Soc. 127, 13245–13252 (2005).

J. Gevertz, H. H. Gan, and T. Schlick, In Vitro RNA Random Pools are Not Structurally Diverse: A Computational Analysis, RNA 11, 853–863 (2005).

J. Sun, Q. Zhang, and T. Schlick, Electrostatic Mechanism of Nucleosomal Array Folding Revealed by Computer Simulation, Proc. Natl. Acad. Sci. 102, 8180–8185 (2005).

N. Kim, N. Shiffeldrim, H. H. Gan, and T. Schlick, Candidates for Novel RNA Topologies, J. Mol. Biol. 341, 1129–1144 (2004).

L. Yang, K. Arora, W. A. Beard, S. H. Wilson, and T. Schlick, Critical Role of Magnesium Ions in DNA Polymerase Beta’s Closing and Active Site Assembly, J. Amer. Chem. Soc. 126, 8441–8453 (2004).

R. Radhakrishnan and T. Schlick, Biomolecular Free Energy Profiles by a Shooting/Umbrella Sampling Protocol, “BOLAS”, J. Chem. Phys. 121, 2436–2444 (2004).

R. Radhakrishnan and T. Schlick, Orchestration of Cooperative Events in DNA Synthesis and Repair Mechanism Unraveled by Transition Path Sampling of DNA Polymerase Beta’s Closing, Proc. Natl. Acad. Sci. USA 101, 5970–5975 (2004).

Book: Molecular Modeling and Simulation: An Interdisciplinary Guide, New York: Springer-Verlag, 2002.  For more information about this book, click here.
For a detailed list of Professor Schlick Group's publication, click here.

Affiliated with other departments or programs
Department of Biochemistry, New York University School of Medicine Courant Institute of Mathematical Science (Department of Mathematics and Computer Science)

External Affiliations
American Association for the Advancement of Science American Chemical Society Association for Women in Mathematics American Mathematical Society Biophysical Society Society for Mathematical Biology Society of Industrial and Applied Mathematics

Searle Scholar (1991-1994) National Science Foundation (NSF) Presidential Young Investigator (1991-1996) New York University Distinguished Recent Alumna (1993) Alfred P. Sloan Research Fellow (1993-1997) Howard Hughes Medical Institute Associate Investigator (1994-2003) Outstanding Women in Science, AWIS (2000) John Simon Guggenheim Memorial FoundationFellow (2000-2001) Agnes Fay Morgan Research Award in Chemistry, Iota Sigma Pi (2003) American Association for the Advancement of Science (AAAS) Fellow (2004) American Physical Society (APS) Fellow (2005) 2005 Businesswoman of the Year (2006)

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