Synthetic Chemistry

Hybrid DNA/organic compounds offer ready access to novel structures. A hybrid DNA/organic macrocycle was prepared by linking an amide across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5’- and 3’-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies. (J. Am. Chem. Soc. 2008, 130, 10882-3)

Synthetic Chemistry Faculty

	Paramjit S Arora Design and synthesis of peptidomimetics; inhibitors of protein-protein interactions; small molecule ligands for nucleic acids; artificial control of gene expression.
	James Canary Triggered chiral materials; fluorescent chemosensors;DNA-directed assembly of organic polymers; biomedical molecular imaging agents; anticancer imaging and therapeutic agents.
	Bart Kahr
	Kent Kirshenbaum Design and synthesis of peptidomimetics; multivalent display; macromolecular design; biomimetic chemistry
	Lara K Mahal
	David I. Schuster Fullerene chemistry; materials for electron and energy transfer.
	Marc A. Walters Bioinorganic chemistry; study of redox potentials in electron transfer proteins; noncovalent influence on the modulation of the redox potentials
	Michael D Ward Materials and solid-state chemistry, supramolecular chemistry and self-assembly; interfacial chemistry; crystallization; atomic force microscopy; pathological biomineralization; crystals in disease
	Marcus Weck Polymer methodology, supramolecular polymerscience; self-assembly; polymeric organic light-emitting diodes; polymers as support in homogeneous catalysis.

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