Paramjit Arora
Associate Professor of ChemistryEmail:
Phone: 212-998-8470
Office: Brown Building, 29 Washington Place, Room 360
Lab Homepage
Areas of Research/Interest
Bioorganic chemistry
Research Description
Research in the Arora Lab utilizes expertise in organic chemistry to develop synthetic inhibitors of protein-protein and protein-nucleic acids interactions. These interactions are difficult targets for typical small molecule ligands. We are using a rational design approach to prepare synthetic scaffolds that offer highly specific reagents for biological studies.
Publications
Jochim, A. L.; Arora P. S. “Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors.” ACS Chem. Biol. 2010, 5, 919-923.
Tošovská, P.; Arora, P. S. “Oligooxopiperazines as Nonpeptidic α-Helix Mimetics." Org. Lett. 2010, 12, 1588-1591.
Henchey, L. K.; Kushal, S.; Dubey, R.; Chapman, R. N.; Olenyuk, B. Z.; Arora, P. S. "Inhibition of Hypoxia Inducible Factor 1–Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix." J. Am. Chem. Soc. 2010, 132, 941-943.
Chapman, R. N.; Kulp, J. L. III; Patgiri, A.; Kallenbach, N. R.; Bracken, C.; Arora, P. S. “Trapping a Folding Intermediate of the Alpha-Helix: Stabilization of the Pi-Helix.” Biochemistry (Accelerated Publication) 2008, 47, 4189-4195.
Wang, D.; Liu, J.; Zheng, Q.; Lu, M.; Arora, P. S. “Atomic Structure of a Short Alpha-Helix Stabilized by a Main Chain Hydrogen Bond Surrogate”. J. Am. Chem. Soc. 2008, 130, 4334-4337.
Wang, D.; Lu, M.; Arora, P.S. “Inhibition of HIV-1 Fusion by Hydrogen-Bond Surrogate Based Alpha-Helices.” Angew. Chem. Int. Ed. 2008, 47, 1879-1882.
Angelo, N.; Arora, P. S. “Solution and Solid Phase Synthesis of Triazole Oligomers that Display Protein-like Functionality.” J. Org. Chem. 2007, 72, 7963-7967.
Chapman, R. N.; Arora, P. S. “Optimized Synthesis of Hydrogen-Bond Surrogate Helices: Surprising Effects of Microwaves on the Activity of Grubbs Catalysts.” Org. Lett. 2006, 8, 5825-5828.
Wang, D.; Chen, K.; Kulp, J. L. III; Arora, P. S. “Evaluation of Biologically Relevant Short Alpha-Helices Stabilized by a Main-Chain Hydrogen-Bond Surrogate.” J. Am. Chem. Soc. 2006, 128, 9248-9256.
Angelo, N.; Arora, P. S. “Nonpeptidic Foldamers from Amino Acids: Synthesis and Characterization of 1,3-Substituted Triazole Oligomers.” J. Am. Chem. Soc. 2005, 127, 17134-17135.
Fellowships/Honors
American Cancer Society Postdoctoral Fellowship (1999-2002), James D. Watson Investigator Award (2002), Cottrell Scholar Award (2005), Whitehead Fellowship in Biomedical and Biological Sciences (2005-2006), Golden Dozen Teaching Award (2007)
