Paramjit Arora

Professor of Chemistry
Phone: 212-998-8470
Office: Brown Building, 29 Washington Place, Room 360
Lab Homepage

Areas of Research/Interest
Bioorganic chemistry

Research Description
Research in the Arora Lab utilizes expertise in organic chemistry to develop synthetic inhibitors of protein-protein and protein-nucleic acids interactions. These interactions are difficult targets for typical small molecule ligands. We are using a rational design approach to prepare synthetic scaffolds that offer highly specific reagents for biological studies.

Patgiri, A.; Joy, S. T.; Arora, P. S. “Nucleation Effects in Peptide Foldamers.” J. Am. Chem. Soc. 2012, 134, 11495-11502.

Mahon, A. B.; Arora, P. S. "Design, Synthesis and Protein-Targeting properties of thioether-linked hydrogen bond surrogate helices." Chem. Commun. 2012, 48, 1416-1418.

Bullock, B. N.; Jochim, A. L.; Arora, P. S. “Assessing Helical Protein Interfaces for Inhibitor Design.” J. Am. Chem. Soc. 2011, 133, 14220-14223.

Patgiri, A.; Yadav, K.; Arora, P. S.; Bar-Sagi, D. “An Orthosteric Inhibitor of the Ras–Sos Interface.” Nature Chem. Biol. 2011, 7, 585-587.

Henchey, L. K.; Kushal, S.; Dubey, R.; Chapman, R. N.; Olenyuk, B. Z.; Arora, P. S. "Inhibition of Hypoxia Inducible Factor 1–Transcription Coactivator Interaction by a Hydrogen Bond Surrogate Alpha-Helix." J. Am. Chem. Soc. 2010, 132, 941-943.

Jochim, A. L.; Arora P. S. “Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors.” ACS Chem. Biol. 2010, 5, 919-923.

Tošovská, P.; Arora, P. S. “Oligooxopiperazines as Nonpeptidic α-Helix Mimetics." Org. Lett. 2010, 12, 1588-1591.

Patgiri, A.; Jochim, A. L.; Arora, P. S. “A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in Alpha-Helical Conformation.” Acc. Chem. Res. 2008, 41, 1289-1300.

Wang, D.; Liu, J.; Zheng, Q.; Lu, M.; Arora, P. S.  “Atomic Structure of a Short Alpha-Helix Stabilized by a Main Chain Hydrogen Bond Surrogate”.  J. Am. Chem. Soc. 2008, 130, 4334-4337.

Wang, D.; Lu, M.; Arora, P.S. “Inhibition of HIV-1 Fusion by Hydrogen-Bond Surrogate Based Alpha-Helices.” Angew. Chem. Int. Ed. 2008, 47, 1879-1882.

American Cancer Society Postdoctoral Fellowship (1999-2002), James D. Watson Investigator Award (2002), Cottrell Scholar Award (2005), Whitehead Fellowship in Biomedical and Biological Sciences (2005-2006), Golden Dozen Teaching Award (2007)

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