Lara K. MahalAssociate Professor of Chemistry
B.A., University of California at Santa Cruz, Phi Beta Kappa Ph.D., University of California at Berkeley Postdoctoral Fellow, Sloan-Kettering Institute
Office: Silver Center, 100 Washington Square East, Room 823
Areas of Research/Interest
Chemical Biology, Glycomics, Molecular Recognition, Organic Chemistry.
Carbohydrates are critical in a myriad of important biological processes including intra-cellular communication, inflammation and bacterial and viral infections. Our laboratory merges chemistry and biology to understand glycosylation using systems-based approaches. These include the creation and utilization of array technologies, cellular sensors and probes for glycosylation. We focus on four major areas of interest 1. Mapping glycan regulatory networks, including microRNA/glycan networks, 2. Studying the role of glycans and their regulators in cancer metastasis. 3. Understanding the relationship between the glycome and the microbiome (bacteria and viruses) and 4. Further developing lectin microarrays and other technologies for analyzing and modulating glycosylation.
Wang, L.; Koppolu, S.; Chappell, C.; Moncla, B.J.; Hillier, S.L.; Mahal, L.K. Studying the Effects of Reproductive Hormones and Bacterial Vaginosis on the Glycome of Lavage Samples from the Cervicovaginal Cavity. Plos One 2015, in press.
T.; Liu, Z.; Paradkar, A.V.; Vaiana, C.A.; Koppolu, S.; Agrawal, P.;
Mahal, L.K. A miRNA proxy approach reveals hidden functions of
glycosylation. Proc. Natl. Acad. Sci., USA 2015, in press.
Kasper, B.T.; Koppolu, S.; Mahal, L.K. Insights into MiRNA Regulation of the Human Glycome. Biochem. Biophys. Res. Commun. 2014, 445, 774-9.
Agrawal, P.; Kurcon, T.; Pilobello, K.T.; Rakus, J.F.; Koppolu, S.; Liu, Z.; Batista, B.S.; Eng, W.S., Hsu, K.-L.; Liang, Y.; Mahal, L.K. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proc. Natl. Acad. Sci., USA, 2014, 111, 4338-43.
Liang, Y.; Eng, W.S.; Colquhoun, D.R.; Dinglasan, R.R.; Graham, D.R.; Mahal, L.K. Complex N-linked Glycans Serve as a Determinant for Exosome/Microvesicle Cargo Recruitment. J. Biol. Chem., 2014, 289, 32526-37.
Hsu, K.-L.; Gildersleeve, J.C.; Mahal, L.K. A simple strategy for the creation of a recombinant lectin microarray, Mol. BioSystems, 2008, 4, 654-662.
Mahal, L.K. Glycomics: Towards Bioinformatic Approaches to Understanding Glycosylation, Anti-Cancer Agents Med. Chem. 2008, 8, 37-51.
University of California, Regents Scholar (1993-1995), ACS Division of Medicinal Chemistry Predoctoral Fellow (1998-1999), Jane Coffin Childs Cancer Research Fellow (2000-2003), Beckman Young Investigator (2004-2007), NSF-CAREER Award (2007-present), Sloan Foundation Fellow (2008-present), NIH Director's Innovator Award (2008-present).