Dirk Trauner

Professor of Chemistry
Email:
Phone: 212-998-3747
Office: Silver Center, 100 Washington Square East, Room 712
Lab Homepage

Areas of Research/Interest
Chemical Biology, Chemical Neurosciences, Natural Product Chemistry, Chemical Synthesis

Research Description
Neuroscience is one of the most exciting areas of research and synthetic chemistry can contribute much to its further development. Our current focus lies on the functional manipulation of ion channels and GPCRs using synthetic photoswitches, usually azobenzenes. The artificial photoreceptors so obtained can be inserted into neurons and other cell types and can be used to control various biological pathways with light (Photopharmacology). One of our major biological goals is the restoration of vision in the blind using synthetic photoswitches. The reach of photopharmacology, however, goes well beyond applications in neuroscience and sensory physiology. It is already clear that this approach is particular useful to controlling the highly dynamic systems that underlie cell motility, cell division and (unwanted) proliferation. As such, photopharmacology provides powerful tools for cell biology and could open a new direction in targeted cancer chemotherapy. As our program in chemical biology grows, we remain are dedicated to chemical synthesis and natural product chemistry. We are convinced that the vast majority of natural products have not yet been found and that a wealth of interesting chemistry and biology awaits discovery. As synthetic organic chemists, we are intrigued by the structural beauty and functional sophistication of these molecules. Through total synthesis, we gain insight into their mechanism of action and biosynthetic origin. In addition, the total synthesis of complex natural products provides an ideal platform for the invention or discovery of new synthetic methodology or the validation of modern reactions in a challenging environment.

Publications
"Optical Control of AMPA Receptors Using a Photoswitchable Quinoxaline-2,3-dioneAntagonist" Barber, D. M.; Liu, S.-A.; Gottschling, K.; Sumser, M.;Hollmann, M.; Trauner, D. Chem. Sci. 2016, 7, DOI: 10.1039/C6SC01621A.

"PhotoswitchableDiacylglycerols Enable Optical Control of Protein Kinase C" Frank, J. A.;Yushchenko, D.; Hodson, D. A.; Lipstein, N.; Nagpal, J.; Rutter, G. A.; Rhee,J.-S.; Gottschalk, A.; Brose, N.; Schultz, C.; Trauner. D. Nature Chem.Biol. 2016, 12, 755-762.

"ExpedientSynthesis of Lycopalhine A"Williams. B., Trauner, D.* Angew. Chemie Int. Ed. 2016, 55, 2191-2194.

"An Eight-Step Synthesis of EpicolactoneReveals its Biosynthetic Origin" Ellerbrock, P.; Armanino. N.; Ilg. M. K.;Webster, R.; Trauner, D. Nature Chemistry. 2015, 7, 879-882.

"A Highly Convergent and Biomimetic TotalSynthesis of Portentol" Cheng, B.; Trauner, D. J. Am. Chem. Soc. 2015, 137, 13800-13803.

"A Roadmap to Success inPhotopharmacology" Broichhagen, J.; Frank, J.A.; Trauner, D. Acc. Chem.Res., 2015, 48, 1947-1960.

"The Total Synthesis of (–)-Nitidasin"Hog, D.; Huber. F.; Mayer, P.; Trauner, D. Angew. Chem. Int. Ed. 2014, 53,8413-8517.

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