Chemical Biology

α-Helix Mimetics Deyun Wang, Min Lu, and Paramjit S. Arora* Angew. Chem. Int. Ed. 2008, 47, 1879-1882. Inhibition of HIV-1 Fusion by Hydrogen Bond Surrogate Based α-Helices An artificial α-helix obtained by replacing an N-terminal main-chain i and i+4 hydrogen bond with a carbon-carbon bond inhibits gp41-mediated cell fusion.This work suggests that hydrogen bond surrogate derived helices may provide a general class of scaffolds for the generation of leads against viral entry.

Chemical Biology Faculty

	Paramjit S Arora Design and synthesis of peptidomimetics; inhibitors of protein-protein interactions; small molecule ligands for nucleic acids; artificial control of gene expression.
	James Canary DNA mimetics, manganese(II)-based probes for ion channel and neurobiology studies, biomedical molecular imaging
	Nicholas E. Geacintov DNA lesions in cancer; mechanisms of DNA modification; structure and properties of damaged DNA
	Neville R. Kallenbach Protein structure function and folding; model helix and beta-sheet structures; biophysical chemistry of proteins and nucleic acids; anti-infectious peptides derived from innate immune system
	Kent Kirshenbaum
	Tamar Schlick Computational and structural chemical biology, including biomolecular modeling and simulation of regulatory protein/nucleic acid systems such as DNA polymerases, chromatin fibers, and RNAs in the goal of novel RNA design and drug/DNA design
	Nadrian C. Seeman Biophysical chemistry of intermediates in genetic recombination and structural DNA nanotechnology, including nanoconstruction of DNA objects, lattices and devices; nanorobotics and nanofabrication; DNA-based computation.
	Vladimir Shafirovich Biological impact of oxidatively modified DNA bases; laser spectroscopy studies of oxidative DNA damage
	Robert Shapiro Effects of mutagens on the structure and function of nucleic acids; origins of life

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