Biomolecular and Biophysical Chemistry

Trapping a Folding Intermediate of the Alpha-Helix: Stabilization of the Pi-Helix Ross Chapman, John L. Kulp III Anupam Patgiri, Neville R. Kallenbach, Clay Bracken and Paramjit S. Arora The Arora Lab reports the design, synthesis and characterization of a short peptide trapped in a pi-helix configuration. This metastable conformation is infrequently observed in proteins but is thought to be a key protein folding intermediate. Reference: Biochemistry, 47, 4189–4195, 2008.

Biomolecular and Biophysical Chemistry Faculty

	Nicholas E. Geacintov DNA lesions in cancer; mechanisms of DNA modification; structure and properties of damaged DNA
	Alexej Jerschow molecular imaging, quantification of exchangeable species in tissues, NMR spectroscopy and imaging
	Neville R. Kallenbach
	Kent Kirshenbaum Design and synthesis of peptidomimetics; multivalent display;molecular recognition; macromolecular design; protein folding & protein folding diseases; biomedical imaging
	Tamar Schlick Computer modeling and simulation of regulatory protein/nucleic acid systems; current problems of interest are DNA polymerase fidelity mechanisms, novel RNA design, and chromatin folding and dynamics.
	Nadrian C. Seeman Structural DNA Nanotechnology, including nanoconstruction of DNA ojbects, lattices and devices; nanorobotics and nanofabrication; DNA-based computation; bionanofabrication; bionanorobotics; bionanoelectronics; crystallography.
	Vladimir Shafirovich Biological impact of oxidatively modified DNA bases; laser spectroscopy studies of oxidative DNA damage
	Robert Shapiro Organic and bioorganic chemistry: effects of mutagens on the structure and function of nucleic acids; origins of life
	Yingkai Zhang Theoretical chemistry and computational enzymology; ab initio QM/MM and multiscale simulation methods; histone modifications and recognition; and membrane enzymes.
	Suse Broyde

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